Ubiquitin carboxyl-terminal hydrolase 16

USP16 belongs to peptidase C19 family. It catalyses the deubiquitination of histone H2A in vitro and in vivo and negatively affects cell division (PMID: 10077596). It has high specificity for H2Aub and does not deubiquitinate H2B. USP16 is an important enzymes involved in the regulation of Hox genes and has a significant role in development of an organism. Its H2A deubiquitination activity is essential for subsequent H3 serine 10 phosphorylation to occur during mitosis (PMID: 17914355). USP16 mediated deubiquitination also has a role in DNA damage response where its activity reverses the transcriptionally repressed state at the DSBs (PMID: 20550933).

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Ubiquitin carboxyl-terminal hydrolase 16 infosheet
UniprotKB AccessionQ9Y5T5
Alternative Name(s)Deubiquitinating enzyme 16, Ubiquitin thiolesterase 16, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16
Eraser for PTM/s
EC number
No. of coding genesUbiquitin carboxyl-terminal hydrolase 16 is coded by following 1 non-allelic gene/s
Gene nameubiquitin specific peptidase 16
Gene symbolUSP16
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location21q21
RefSeq mRNANM_001001992.1NM_001032410.1NM_006447.2
RefSeq ProteinNP_001001992.1NP_001027582.1NP_006438.1
Disease associationsNo disease associations known for Ubiquitin carboxyl-terminal hydrolase 16

Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3