Ubiquitin carboxyl-terminal hydrolase 22

USP22 belongs to peptidase C19 family. It is part of TFTC/STAGA complex that catalyses the deubiquitination of histone H2Aub1 and H2Bub1 (PMID: 18206972). USP22 is a signature molecule for cancer stem cells (PMID: 16760651). It is also part of the SAGA complex that performs the deubiquitination of H2Bub and is essential to create a fine balance between the polycomb mediated repression and SAGA mediated activation of transcription. USP22 is implicated in cell cycle progression. Reports suggest that myc helps in the recruitment of USP22 to oncogene promoter sites in cancer stem cells (PMID: 18206973)(PMID: 18469533). USP22 and GCN5 are also involved in the maintenance of telomeres (PMID: 19683498).

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Ubiquitin carboxyl-terminal hydrolase 22 infosheet
UniprotKB AccessionQ9UPT9
Alternative Name(s)Deubiquitinating enzyme 22, Ubiquitin thiolesterase 22, Ubiquitin-specific-processing protease 22
Eraser for PTM/s
EC number
No. of coding genesUbiquitin carboxyl-terminal hydrolase 22 is coded by following 1 non-allelic gene/s
Gene nameubiquitin specific peptidase 22
Gene symbolUSP22
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sUSP3L
Chromosomal location17p11.2
RefSeq mRNANM_015276.1
RefSeq ProteinNP_056091.1
Disease associations
Cancer: Colorectal cancer; PMID: 21337558
Cancer: Breast cancer; PMID: 21691749

Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3