Ubiquitin carboxyl-terminal hydrolase 22
USP22 belongs to peptidase C19 family. It is part of TFTC/STAGA complex that catalyses the deubiquitination of histone H2Aub1 and H2Bub1 (PMID: 18206972). USP22 is a signature molecule for cancer stem cells (PMID: 16760651). It is also part of the SAGA complex that performs the deubiquitination of H2Bub and is essential to create a fine balance between the polycomb mediated repression and SAGA mediated activation of transcription. USP22 is implicated in cell cycle progression. Reports suggest that myc helps in the recruitment of USP22 to oncogene promoter sites in cancer stem cells (PMID: 18206973)(PMID: 18469533). USP22 and GCN5 are also involved in the maintenance of telomeres (PMID: 19683498).
| UniprotKB Accession | Q9UPT9 |
|---|---|
| Alternative Name(s) | Deubiquitinating enzyme 22, Ubiquitin thiolesterase 22, Ubiquitin-specific-processing protease 22 |
| Eraser for PTM/s | |
| EC number | 3.4.19.12 |
| No. of coding genes | Ubiquitin carboxyl-terminal hydrolase 22 is coded by following 1 non-allelic gene/s |
| Gene name | ubiquitin specific peptidase 22 |
| Gene symbol | USP22 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | USP3L |
| Aliases | KIAA1063 |
| GeneID | 23326 |
| Chromosomal location | 17p11.2 |
| HGNC | 12621 |
| Unigene | Hs.462492 |
| MIM | 612116 |
| RefSeq mRNA | NM_015276.1 |
| RefSeq Protein | NP_056091.1 |
| Disease associations | Cancer: Colorectal cancer; PMID: 21337558 Cancer: Breast cancer; PMID: 21691749 |
Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3