Lys-63-specific deubiquitinase BRCC36

BRCC36 is a member of peptidase M67A family. It is reported to form a complex with Rap80 to catalyse the deubiquitination of gamma-H2A.X during DNA damage response (PMID: 19202061). Diubiquitinated H2A and H2A.X are other substrates for BRCC36. It specifically mediates the removal of 'Lys-63'-linked polyubiquitin chains (PMID: 20656690). It is part of two complexes namely BRCA1-RAP80 complex and BRCC36 isopeptidase complex (BRISC). Experimental evidence suggest that BRCC36 is catalytically active only when present in the complex and both the complexes have different interacting partners for BRCC36 (PMID: 20656689).

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Lys-63-specific deubiquitinase BRCC36 infosheet
UniprotKB AccessionP46736
Alternative Name(s)BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36
Eraser for PTM/s
EC number 3.4.19.-
No. of coding genesLys-63-specific deubiquitinase BRCC36 is coded by following 1 non-allelic gene/s
Gene nameBRCA1/BRCA2-containing complex, subunit 3
Gene symbolBRCC3
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sCXorf53
AliasesC6.1A, BRCC36
Chromosomal locationXq28
RefSeq mRNANM_001018055.1NM_024332.2
RefSeq ProteinNP_001018065.1NP_077308.1
Disease associationsNo disease associations known for Lys-63-specific deubiquitinase BRCC36

Lysine deubiquitinases Histone H2A deubiquitinase MYSM1, Lys-63-specific deubiquitinase BRCC36, Ubiquitin carboxyl-terminal hydrolase 16, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin carboxyl-terminal hydrolase 3