Protein-arginine deiminase type-4

PADI4 belongs to the protein arginine deiminase family. It is shown to catalyse deimination of arginine in a calcium dependent manner, in order to convert them to citrulline. PADI4 catalyses deimination at R2, R8, R17, and R26 position on H3. This activity inhibits the methylation of these residues by CARM1. Deimination process leads to transcriptional repression of target genes (PMID: 15339660). It also catalyses the deimination at histone H2A and H4 at the arginine 3 position in human granulocytes (PMID: 15823041). PADI4 expression levels are significantly upregulated in many malignant tumours (PMID: 19183436). Recently reports show that PADI4 associates with HDAC1 to mediate transcriptional repression (PMID: 19581286).

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Protein-arginine deiminase type-4 infosheet
UniprotKB AccessionQ9UM07
Alternative Name(s)HL-60 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV
Writer for PTM/s H3R2ci, H3R8ci, H3R17ci, H3R26ci, H2AR3ci, H4R3ci
EC number
No. of coding genesProtein-arginine deiminase type-4 is coded by following 1 non-allelic gene/s
Gene namepeptidyl arginine deiminase, type IV
Gene symbolPADI4
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sPADI5
AliasesPAD, PDI5, PDI4
Chromosomal location1p36.13
RefSeq mRNANM_012387.2
RefSeq ProteinNP_036519.2
Disease associations
Cancer: ALL; PMID: 19183436

Arginine deiminases Protein-arginine deiminase type-4