Core histone macro-H2A.2

Levels of macroH2A2 decrease significantly in malignant cells that suggests that it plays a role in tumour suppression (PMID: 21179167). It is also reported to regulate the expression of HOXA cluster genes in pluripotent cells along with macroH2A1 (PMID: 19734898). Shown to play an important role in predicting the recurrence of lung cancer (PMID: 19648962). It plays a significant role in the process of X chromosome inactivation (PMID: 11331621).

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Core histone macro-H2A.2 (Histone macroH2A2, mH2A2) infosheet

UniprotKB Accession

Q9P0M6

Alternative Name(s)

No. of coding genes

Core histone macro-H2A.2 is coded by following 1 non-allelic gene/s

Gene name

H2A histone family, member Y2

Gene symbol

H2AFY2

Promoter region (-700 TSS +300)