Histone H2A-Bbd type 2/3

Histone H2A.Bbd is only 48% similar to the major forms of histone H2A. It is essentially observed on the active X chromosome and the inactive X chromosome is devoid of this variant (PMID: 11266453). H2A.Bbd forms a highly unstable nucleosome in in vitro condition and wraps only 118 base pairs of DNA fragment (PMID: 15257289, PMID: 17726088). It has a characteristic 6 arginine repeat in its N terminal region (PMID: 11266453). It is recently shown to be involved in the spermiogenesis process and might contribute to the histone-to-protamine exchange in sperms (PMID: 20008104).

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Histone H2A-Bbd type 2/3 infosheet
UniprotKB AccessionP0C5Z0
Alternative Name(s)H2A Barr body-deficient (H2A.Bbd)
No. of coding genesHistone H2A-Bbd type 2/3 is coded by following 2 non-allelic gene/s
Gene nameH2A histone family, member B2H2A histone family, member B3
Gene symbolH2AFB2H2AFB3
Promoter region (-700 TSS +300)Get sequenceGet sequence
Previous Symbol/sH2AFB
Chromosomal locationXq28Xq28
RefSeq mRNANM_001017991.1NM_080720.1
RefSeq ProteinNP_001017991.1NP_542451.1
Disease associationsNo disease associations known for Histone H2A-Bbd type 2/3

Histone H2A variants Core histone macro-H2A.1, Core histone macro-H2A.2, Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A-Bbd type 1, Histone H2A-Bbd type 2/3, Histone H2A.J, Histone H2A.V, Histone H2A.x, Histone H2A.Z