Histone H2A-Bbd type 2/3
Histone H2A.Bbd is only 48% similar to the major forms of histone H2A. It is essentially observed on the active X chromosome and the inactive X chromosome is devoid of this variant (PMID: 11266453). H2A.Bbd forms a highly unstable nucleosome in in vitro condition and wraps only 118 base pairs of DNA fragment (PMID: 15257289, PMID: 17726088). It has a characteristic 6 arginine repeat in its N terminal region (PMID: 11266453). It is recently shown to be involved in the spermiogenesis process and might contribute to the histone-to-protamine exchange in sperms (PMID: 20008104).
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| UniprotKB Accession | P0C5Z0 | |
|---|---|---|
| Alternative Name(s) | H2A Barr body-deficient (H2A.Bbd) | |
| No. of coding genes | Histone H2A-Bbd type 2/3 is coded by following 2 non-allelic gene/s | |
| Gene name | H2A histone family, member B2 | H2A histone family, member B3 |
| Gene symbol | H2AFB2 | H2AFB3 |
| Promoter region (-700 TSS +300) | Get sequence | Get sequence |
| Previous Symbol/s | H2AFB | |
| Aliases | ||
| GeneID | 474381 | 83740 |
| Chromosomal location | Xq28 | Xq28 |
| HGNC | 18298 | 14455 |
| Unigene | Hs.534498 | Hs.632841 |
| MIM | 300445 | |
| RefSeq mRNA | NM_001017991.1 | NM_080720.1 |
| RefSeq Protein | NP_001017991.1 | NP_542451.1 |
| Disease associations | No disease associations known for Histone H2A-Bbd type 2/3 | |
Histone H2A variants Core histone macro-H2A.1, Core histone macro-H2A.2, Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A-Bbd type 1, Histone H2A-Bbd type 2/3, Histone H2A.J, Histone H2A.V, Histone H2A.x, Histone H2A.Z