Histone H2A-Bbd type 1
Histone H2A.Bbd is only 48% similar to the major forms of histone H2A. It is essentially observed on the active X chromosome and the inactive X chromosome is devoid of this variant (PMID: 11266453). H2A.Bbd forms a highly unstable nucleosome in in vitro condition and wraps only 118 base pairs of DNA fragment (PMID: 15257289)(PMID: 17726088). It has a characteristic 6 arginine repeat in its N terminal region (PMID: 11266453). It is recently shown to be involved in the spermiogenesis process and might contribute to the histone-to-protamine exchange in sperms (PMID: 20008104).
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UniprotKB Accession | P0C5Y9 |
---|---|
Alternative Name(s) | H2A Barr body-deficient (H2A.Bbd) |
No. of coding genes | Histone H2A-Bbd type 1 is coded by following 1 non-allelic gene/s |
Gene name | H2A histone family, member B1 |
Gene symbol | H2AFB1 |
Promoter region (-700 TSS +300) | Get sequence |
Previous Symbol/s | |
Aliases | |
GeneID | 474382 |
Chromosomal location | Xq28 |
HGNC | 22516 |
Unigene | Hs.592246 |
MIM | |
RefSeq mRNA | NM_001017990.1 |
RefSeq Protein | NP_001017990.1 |
Disease associations | No disease associations known for Histone H2A-Bbd type 1 |
Histone H2A variants Core histone macro-H2A.1, Core histone macro-H2A.2, Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A-Bbd type 1, Histone H2A-Bbd type 2/3, Histone H2A.J, Histone H2A.V, Histone H2A.x, Histone H2A.Z