Histone H2A.Z
H2AZ gene is located on chromosome number 4. Expression is replication independent (PMID: 1697587 ). Reports argue that H2AZ does not self-propogate unto the surrounding nucleosomes and hence might have restricted epigenetic features (PMID: 16809769). p400 (ATP-dependent complex, homolog of Swr1) is reported to be important for the localization of H2AZ in the chromatin and this function regulates p21 transcription (PMID: 17671089).
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UniprotKB Accession | P0C0S5 | |||||||||||||||
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Alternative Name(s) | ||||||||||||||||
No. of coding genes | Histone H2A.Z is coded by following 1 non-allelic gene/s | |||||||||||||||
Gene name | H2A histone family, member Z | |||||||||||||||
Gene symbol | H2AFZ | |||||||||||||||
Promoter region (-700 TSS +300) | Get sequence | |||||||||||||||
Previous Symbol/s | H2AZ | |||||||||||||||
Aliases | H2A.Z | |||||||||||||||
GeneID | 3015 | |||||||||||||||
Chromosomal location | 4q23 | |||||||||||||||
HGNC | 4741 | |||||||||||||||
Unigene | Hs.119192 | |||||||||||||||
MIM | 142763 | |||||||||||||||
RefSeq mRNA | NM_002106.3 | |||||||||||||||
RefSeq Protein | NP_002097.1 | |||||||||||||||
Disease associations |
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Histone H2A variants Core histone macro-H2A.1, Core histone macro-H2A.2, Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A-Bbd type 1, Histone H2A-Bbd type 2/3, Histone H2A.J, Histone H2A.V, Histone H2A.x, Histone H2A.Z