Histone H2A.Z

H2AZ gene is located on chromosome number 4. Expression is replication independent (PMID: 1697587 ). Reports argue that H2AZ does not self-propogate unto the surrounding nucleosomes and hence might have restricted epigenetic features (PMID: 16809769). p400 (ATP-dependent complex, homolog of Swr1) is reported to be important for the localization of H2AZ in the chromatin and this function regulates p21 transcription (PMID: 17671089).

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Histone H2A.Z (H2A/z) infosheet
UniprotKB AccessionP0C0S5
Alternative Name(s)
No. of coding genesHistone H2A.Z is coded by following 1 non-allelic gene/s
Gene nameH2A histone family, member Z
Gene symbolH2AFZ
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sH2AZ
Chromosomal location4q23
RefSeq mRNANM_002106.3
RefSeq ProteinNP_002097.1
Disease associations
CancerBreast cancer20666725
CancerProstate cancer21788347
CancerB cell lymphomas20709945
CancerBreast cancer15608061

Histone H2A variants Core histone macro-H2A.1, Core histone macro-H2A.2, Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A-Bbd type 1, Histone H2A-Bbd type 2/3, Histone H2A.J, Histone H2A.V, Histone H2A.x, Histone H2A.Z