Dual specificity protein phosphatase 1
In vitro report of H3S10 phosphatase activity (PMID: 19020052). It is reported to mediate both threonine as well as tyrosine dephosphorylation and is implicated in many depressive disorders (PMID: 20953200).
| UniprotKB Accession | P28562 |
|---|---|
| Alternative Name(s) | Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1 (MAP kinase phosphatase 1, MKP-1), Protein-tyrosine phosphatase CL100 |
| Eraser for PTM/s | H3S10ph |
| EC number | 3.1.3.16, 3.1.3.48 |
| No. of coding genes | Dual specificity protein phosphatase 1 is coded by following 1 non-allelic gene/s |
| Gene name | dual specificity phosphatase 1 |
| Gene symbol | DUSP1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | PTPN10 |
| Aliases | HVH1, CL100, MKP-1 |
| GeneID | 1843 |
| Chromosomal location | 5q35.1 |
| HGNC | 3064 |
| Unigene | Hs.171695 |
| MIM | 600714 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | Behavioural disorder: Depression; PMID: 20953200 Cancer: Non-small-cell Lung cancer (NSCLC); PMID: 20890299 |
Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit