Eyes absent homolog 1

EYA1 is involved in the dephosphorylation of histone H2A.X at the tyrosine 142 residue. This activity is supposed to play an important role in deciding whether upon DNA damage, the cell proceeds for apoptosis or the damage caused is repairable and the cell should survive (PMID: 19234442).

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Eyes absent homolog 1 infosheet
UniprotKB AccessionQ99502
Alternative Name(s)
Eraser for PTM/s H2AY142ph
EC number
No. of coding genesEyes absent homolog 1 is coded by following 1 non-allelic gene/s
Gene nameeyes absent homolog 1 (Drosophila)
Gene symbolEYA1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sBOR
Chromosomal location8q13.3
RefSeq mRNANM_000503.4NM_172058.2NM_172059.2NM_172060.2
RefSeq ProteinNP_000494.2NP_742055.1NP_742056.1NP_742057.1
Disease associations
Other: Branchio-oto-renal syndrome (BOR); PMID: 18220287

Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit