Serine/threonine-protein phosphatase 4 catalytic subunit
PP4C belongs to PPP phosphatase family. It is reported to dephosphorylate gamma-H2AX (H2AS139ph; universal DNA damage marker) that form during DNA replication at the sites of DNA damage. Silencing of PP4C causes increase in gamma-H2AX but ATR and Checkpoint proteins remain unaffected (PMID: 18614045, PMID: 18758438). PP4C directly interacts with HDAC3 and this interaction modulates the activity of HDAC3 (PMID: 15805470). PP4C is also shown to be located at microtubule organising centre at centrosomes and has some function in microtubule organisation (PMID: 10769191).
| UniprotKB Accession | P60510 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | H2AS139ph |
| EC number | |
| No. of coding genes | Serine/threonine-protein phosphatase 4 catalytic subunit is coded by following 1 non-allelic gene/s |
| Gene name | protein phosphatase 4, catalytic subunit |
| Gene symbol | PPP4C |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PP4, PPX |
| GeneID | 5531 |
| Chromosomal location | 16p11.2 |
| HGNC | 9319 |
| Unigene | Hs.534338 |
| MIM | 602035 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | No disease associations known for Serine/threonine-protein phosphatase 4 catalytic subunit |
Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit