Protein phosphatase 1D
WIP1 belongs to the PP2C family. It dephosphorylates gamma-H2AX (H2AS139ph; universal DNA damage marker), in vitro as well as in vivo. It is essential for suppressing DNA damage response after completion of DNA repair (PMID: 20118229).
| UniprotKB Accession | O15297 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | H2AS139ph |
| EC number | |
| No. of coding genes | Protein phosphatase 1D is coded by following 1 non-allelic gene/s |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Gene symbol | PPM1D |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | Wip1, PP2C-DELTA |
| GeneID | 8493 |
| Chromosomal location | 17q23.3 |
| HGNC | 9277 |
| Unigene | Hs.286073 |
| MIM | 605100 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | Cancer: Breast cancer; PMID: 12021784 Cancer: Neuroblastoma; PMID: 12702577 |
Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit