H2AS139ph
DNA repair-deficient cells exhibit a substantially reduced ability to increase the phosphorylation of H2AX in response to ionising radiation, consistent with a role for gamma-H2AX in DNA repair (PMID: 10959836). Phosphorylated H2AX Serine 139 (gamma-H2AX), appears during apoptosis concurrently with the initial appearance of high molecular weight DNA fragments. gamma-H2AX forms before the appearance of internucleosomal DNA fragments and the externalisation of phosphatidylserine to the outer membrane leaflet.(PMID: 10734083). gammaH2AX foci are required for recruiting repair and checkpoint protein complexes to the replication break sites as well as during DNA damage responses (PMID: 10959836)(PMID: 12660252). It is also involved in Class switch recombination (PMID: 18370922).
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| Modified variants | Histone H2A.x |
|---|---|
| Writer/s | DNA-dependent protein kinase catalytic subunit, Serine-protein kinase ATM, Serine/threonine-protein kinase ATR |
| Eraser/s | Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit |
| Disease associations | No disease associations known for H2AS139ph |
Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph