H3T6ph
H3T6 phosphorylation via PKC beta I prevents LSD1 from demethylating H3K4, thus maintaining the active methyl marks during androgen-dependent gene activation. Increased levels of PKC beta I and phosphorylated H3T6 positively correlate with high Gleason scores of prostate carcinomas (PMID: 20228790).
Download table as Excel
| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Protein kinase C beta type |
| Eraser/s | |
| Disease associations | No disease associations known for H3T6ph |
Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph