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CENP-A Serine 6 mutant cells show delay in cytokinesis. CENP-A is an essential histone H3-like kinetochore protein incorporated specifically at active centromeres. Thus phosphorylated S6 in kinetochore plays an important role in regulation of cytokinesis (PMID: 11756469). The initial phosphorylation of CENP-A on Ser-6 during prophase is mediated by Aurora-A, but the maintenance of this residue in the phosphorylated state during prometaphase is dependent on Aurora-B and seems to require prior phosphorylation of CENP-A by Aurora-A (PMID: 14667408).

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H3S6ph infosheet
Modified variants Histone H3-like centromeric protein A
Writer/s Serine/threonine-protein kinase 12
Disease associationsNo disease associations known for H3S6ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph