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H3 Threonine 3 phosphorylation occurs specifically during mitosis and is important for normal alignment of chromosomes on the metaphase plate (PMID: 15681610). H3T3ph is often found to be associated with H3K4me3 and H3R8me2 and is thought to work in combination to provide faster progression through metaphase-anaphase checkpoint (PMID: 19622635). H3T3ph marks guide the chromosomal passenger complex (CPC) to the centromere (PMID: 20705812, PMID: 20929775). H3T3 phosphorylation is shown to inhibit TFIID binding at H3K4me mark and thus regulate transcription (PMID: 20953165).

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H3T3ph infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Serine/threonine-protein kinase haspin
Disease associationsNo disease associations known for H3T3ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph