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H3T11 phosphorylation is a mitosis specific modification (PMID: 12560483). H3T11 is phosphorylated at androgen receptor gene targets by PRN1 which acts as a co-activator of androgen receptor dependent transcription. It further promotes demethylation of histone H3 'Lys-9' (H3K9me) by JMJD2C. Levels of PRK1 and phosphorylated H3T11 correlate with Gleason scores of prostate carcinomas (PMID: 18066052).

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H3T11ph infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Death-associated protein kinase 3, Serine/threonine-protein kinase N1
Eraser/s Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Disease associationsNo disease associations known for H3T11ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph