H3T11ph
H3T11 phosphorylation is a mitosis specific modification (PMID: 12560483). H3T11 is phosphorylated at androgen receptor gene targets by PRN1 which acts as a co-activator of androgen receptor dependent transcription. It further promotes demethylation of histone H3 'Lys-9' (H3K9me) by JMJD2C. Levels of PRK1 and phosphorylated H3T11 correlate with Gleason scores of prostate carcinomas (PMID: 18066052).
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| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Death-associated protein kinase 3, Serine/threonine-protein kinase N1 |
| Eraser/s | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
| Disease associations | No disease associations known for H3T11ph |
Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph