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H3Y41ph

Phosphorylation of H3 Tyrosine 41 by JAK2 prevents binding of Heterochromatin protein 1 alpha (HP1 alpha) to hematopoietic oncogene lmo2 promoter which is implicated in leukaemogenesis.(PMID: 19783980).


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H3Y41ph infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Tyrosine-protein kinase JAK2
Eraser/s
Disease associationsNo disease associations known for H3Y41ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph