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H3S28ph

H3S28 phosphorylation is a mitosis specific modification. It appears first at prophase and extends till anaphase (PMID: 11856369). H3S28ph causes displacement of Polycomb repressive complex and converts the adjacent H3K27 methyl mark to H3K27 acetyl mark thus causing gene activation (PMID: 21282660).


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H3S28ph infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Mitogen-activated protein kinase kinase kinase MLT, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine/threonine-protein kinase 12
Eraser/s
Disease associationsNo disease associations known for H3S28ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph