Mitogen-activated protein kinase kinase kinase MLT

MLTK belongs to the STE Ser/Thr protein kinase family. It is reported to mediate H3S28 phosphorylation in vivo and can be enhanced by ultraviolet B light (UVB) or epidermal growth factor (EGF) that causes MLTK to be present in the nucleus (PMID: 15684425).

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Mitogen-activated protein kinase kinase kinase MLT infosheet
UniprotKB AccessionQ9NYL2
Alternative Name(s)Human cervical cancer suppressor gene 4 protein (HCCS-4), Leucine zipper- and sterile alpha motif-containing kinase, MLK-like mitogen-activated protein triple kinase, Mixed lineage kinase-related kinase (MLK-related kinase, MRK), Sterile alpha motif- and leucine zipper-containing kinase AZK
Writer for PTM/s H3S28ph
EC number
No. of coding genesMitogen-activated protein kinase kinase kinase MLT is coded by following 1 non-allelic gene/s
Gene name
Gene symbolUnknown
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location
RefSeq mRNANM_016653.2NM_133646.2
RefSeq ProteinNP_057737.2NP_598407.1
Disease associationsNo disease associations known for Mitogen-activated protein kinase kinase kinase MLT

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2