Mitogen-activated protein kinase kinase kinase 8

Cot belongs to the STE Ser/Thr protein kinase family. It is shown to mediate phosphorylation of histone H3 at Serine 10 position on the c-fos promoter that contributes to its transcriptional regulation ultimately affecting cellular transformations (PMID: 17724252).

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Mitogen-activated protein kinase kinase kinase 8 infosheet
UniprotKB AccessionP41279
Alternative Name(s)Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 (TPL-2)
Writer for PTM/s H3S10ph
EC number
No. of coding genesMitogen-activated protein kinase kinase kinase 8 is coded by following 1 non-allelic gene/s
Gene namemitogen-activated protein kinase kinase kinase 8
Gene symbolMAP3K8
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sCOT, ESTF
AliasesTpl-2, EST, c-COT, MEKK8
Chromosomal location10p11.2
RefSeq mRNA
RefSeq Protein
Disease associationsNo disease associations known for Mitogen-activated protein kinase kinase kinase 8

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2