Serine/threonine-protein kinase 4

MST1 belongs to STE Ser/Thr protein kinase family. Mst1, upon cleavage by caspase-3, phosphorylates H3S14 that is uniquely associated with apoptotic chromatin in species ranging from frogs to humans (PMID: 12757711). This H2B-phosphorylation activity causes immobilization of RCC1 and impairment of NF-kB-p65 nuclear transport which is important for rescuing apoptosis, thus providing a hint at the mechanism of initiation of apoptosis (PMID: 19060893). MST1 is also shown to phosphorylate histone H2A.X at serine 139 position during apoptosis (PMID: 20921231).

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Serine/threonine-protein kinase 4 infosheet
UniprotKB AccessionQ13043
Alternative Name(s)Mammalian STE20-like protein kinase 1 (MST-1), STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2
Writer for PTM/s H2BS14ph, H2AS139
EC number
No. of coding genesSerine/threonine-protein kinase 4 is coded by following 1 non-allelic gene/s
Gene nameserine/threonine kinase 4
Gene symbolSTK4
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesMST1, KRS2, YSK3
Chromosomal location20q11.2-q1
RefSeq mRNANM_006282.2
RefSeq ProteinNP_006273.1
Disease associations
Cancer: Colorectal cancer; PMID: 17277767
Cancer: Prostate cancer; PMID: 18381433

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2