Cyclin-dependent kinase 5
CDK5 has been shown to phosphorylate H1-derived peptides in vitro. Histone H1 proteins are often used as substrates in assays that determine the kinase activity of various cdks (PMID: 11741704).
| UniprotKB Accession | Q00535 |
|---|---|
| Alternative Name(s) | Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit (TPKII catalytic subunit) |
| Writer for PTM/s | |
| EC number | 2.7.11.22 |
| No. of coding genes | Cyclin-dependent kinase 5 is coded by following 1 non-allelic gene/s |
| Gene name | cyclin-dependent kinase 5 |
| Gene symbol | CDK5 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PSSALRE |
| GeneID | 1020 |
| Chromosomal location | 7q36 |
| HGNC | 1774 |
| Unigene | Hs.647078 |
| MIM | 123831 |
| RefSeq mRNA | NM_004935.3 |
| RefSeq Protein | NP_004926.1 |
| Disease associations | No disease associations known for Cyclin-dependent kinase 5 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2