Mitotic checkpoint serine/threonine-protein kinase BUB1

Bub1 phosphorylates histone H2A at threonine 120 in in vitro and in vivo conditions. It colocalises with the H2AT120ph marks at the centromere during metaphase (PMID: 19965387).

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Mitotic checkpoint serine/threonine-protein kinase BUB1 infosheet
UniprotKB AccessionO43683
Alternative Name(s)
Writer for PTM/s H2AT120ph
EC number
No. of coding genesMitotic checkpoint serine/threonine-protein kinase BUB1 is coded by following 1 non-allelic gene/s
Gene namebudding uninhibited by benzimidazoles 1 homolog (yeast)
Gene symbolBUB1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sBUB1L
AliaseshBUB1, BUB1A
Chromosomal location2p11-q21
RefSeq mRNA
RefSeq Protein
Disease associations
Cancer: Lung cancer; PMID: 10835495
Cancer: Colorectal cancer; PMID: 10969775

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2