Protein kinase C beta type

PKC beta belongs to AGC Ser/Thr protein kinase family. It is responsible for threonine 6 phosphorylation of histone H3 which prevents LSD1 from demethylation of H3K9 on androgen dependent activation. This is shown to have implication in prostate cancers (PMID: 20228790). Histones have been used as substrates for demonstrating the phosphorylation activity of PKCs (PMID: 8288312, PMID: 1328200).

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Protein kinase C beta type (PKC-B, PKC-beta) infosheet
UniprotKB AccessionP05771
Alternative Name(s)
Writer for PTM/s H3T6ph
EC number
No. of coding genesProtein kinase C beta type is coded by following 1 non-allelic gene/s
Gene nameprotein kinase C, beta
Gene symbolPRKCB
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sPRKCB2, PKCB, PRKCB1
Chromosomal location16p12
RefSeq mRNANM_002738.6NM_212535.2
RefSeq ProteinNP_002729.2NP_997700.1
Disease associations
Cancer: Hepatocellular carcinoma.; PMID: 19949911
Cancer: Prostate cancer; PMID: 20228790

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2