Inhibitor of nuclear factor kappa-B kinase subunit alpha
IKK-alpha belongs to the Serine/Threonine kinase family. It is shown to be recruited to the NF-kB target gene promoters after cytokine signalling and catalyse the phosphorylation of Serine 10 on histone H3 (PMID: 12789342). Similarly, IKK-alpha is also recruited at oestrogen target gene promoters and mediates the same phosphorylation effect thereby activating the target genes (PMID: 15808510). IKK-alpha regulates the M phase of the cell cycle by phosphorylating Aurora A (PMID: 17102620). It is also reported to activate many Notch target genes in colorectal cancers (PMID: 17190815). It is also shown to phosphorylate and activate the E2F4/p130 repressor complex which further leads to downregulation of E2F target genes preventing cellular growth by an Rb independent manner (PMID: 18542057).
| UniprotKB Accession | O15111 |
|---|---|
| Alternative Name(s) | Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1 (IKK1), Nuclear factor NF-kappa-B inhibitor kinase alpha (NFKBIKA), Transcription factor 16 (TCF-16) |
| Writer for PTM/s | H3S10ph |
| EC number | 2.7.11.10 |
| No. of coding genes | Inhibitor of nuclear factor kappa-B kinase subunit alpha is coded by following 1 non-allelic gene/s |
| Gene name | conserved helix-loop-helix ubiquitous kinase |
| Gene symbol | CHUK |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | TCF16 |
| Aliases | IKK1, IKK-alpha, IkBKA, NFKBIKA, IKKA |
| GeneID | 1147 |
| Chromosomal location | 10q24-q25 |
| HGNC | 1974 |
| Unigene | Hs.198998 |
| MIM | 600664 |
| RefSeq mRNA | NM_001278.3 |
| RefSeq Protein | NP_001269.3 |
| Disease associations | No disease associations known for Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2