Histone H1.0
H1.0 has been observed in growth arrested cells. Its expression is replication independent and occurs throughout the cell cycle. Present on chromosome number 22. mRNA is polyadenylated (PMID: 19587527). H1.0 accumulated majorly in the differentiated cells and its levels are drastically altered during tumorigenesis (PMID: 8001738). Also expressed in hematopoietic progenitor cells in human (PMID: 9013724). Recent report classifies it as a strong condensor of chromatin (PMID: 19794910).
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| UniprotKB Accession | P07305 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alternative Name(s) | Histone H1', Histone H1(0) | |||||||||
| No. of coding genes | Histone H1.0 is coded by following 1 non-allelic gene/s | |||||||||
| Gene name | H1 histone family, member 0 | |||||||||
| Gene symbol | H1F0 | |||||||||
| Promoter region (-700 TSS +300) | Get sequence | |||||||||
| Previous Symbol/s | H1FV | |||||||||
| Aliases | H10 | |||||||||
| GeneID | 3005 | |||||||||
| Chromosomal location | 22q13.1 | |||||||||
| HGNC | 4714 | |||||||||
| Unigene | Hs.727646 | |||||||||
| MIM | 142708 | |||||||||
| RefSeq mRNA | NM_005318.3 | |||||||||
| RefSeq Protein | NP_005309.1 | |||||||||
| Disease associations |
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Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone