Histone H1.4

H1.4 shows a replication dependent expression. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). It has been reported that around 25% of H1.4 is specifically methylated on K25 (reported as H1K26) in human tissues (PMID: 19552482). Phophorylated serine 186 (reported as H1S187) of histone H1.4 variant is specifically associated with ribosomal gene promoters that are transcriptionally active (PMID: 20439994). Histone H1.4 expression is increased during early apoptosis (PMID: 9882631). A recent report classifies it as a strong condenser of chromatin (PMID: 19794910).

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Histone H1.4 infosheet
UniprotKB AccessionP10412
Alternative Name(s)Histone H1b
No. of coding genesHistone H1.4 is coded by following 1 non-allelic gene/s
Gene namehistone cluster 1, H1e
Gene symbolHIST1H1E
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sH1F4
Chromosomal location6p22.1
RefSeq mRNANM_005321.2
RefSeq ProteinNP_005312.1
Disease associationsNo disease associations known for Histone H1.4

Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone