Histone H1.4
H1.4 shows a replication dependent expression. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). It has been reported that around 25% of H1.4 is specifically methylated on K25 (reported as H1K26) in human tissues (PMID: 19552482). Phophorylated serine 186 (reported as H1S187) of histone H1.4 variant is specifically associated with ribosomal gene promoters that are transcriptionally active (PMID: 20439994). Histone H1.4 expression is increased during early apoptosis (PMID: 9882631). A recent report classifies it as a strong condenser of chromatin (PMID: 19794910).
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| UniprotKB Accession | P10412 |
|---|---|
| Alternative Name(s) | Histone H1b |
| No. of coding genes | Histone H1.4 is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 1, H1e |
| Gene symbol | HIST1H1E |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H1F4 |
| Aliases | H1.4 |
| GeneID | 3008 |
| Chromosomal location | 6p22.1 |
| HGNC | 4718 |
| Unigene | Hs.248133 |
| MIM | 142220 |
| RefSeq mRNA | NM_005321.2 |
| RefSeq Protein | NP_005312.1 |
| Disease associations | No disease associations known for Histone H1.4 |
Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone