Histone H1.3
H1.3 expression is replication dependent. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). HL-60 and its differentiated cell types are shown to differ significantly in the presence of H1.3 variant (PMID: 11478838). H1.3 is detected in chromatin throughout the cell cycle whereas other varaints partition between chromatin and cytoplasm in a phase dependent manner (PMID: 20104577). Recent report classifies it as an intermediate condensor of chromatin (PMID: 19794910).
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| UniprotKB Accession | P16402 |
|---|---|
| Alternative Name(s) | Histone H1c |
| No. of coding genes | Histone H1.3 is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 1, H1d |
| Gene symbol | HIST1H1D |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H1F3 |
| Aliases | H1.3 |
| GeneID | 3007 |
| Chromosomal location | 6p21.3 |
| HGNC | 4717 |
| Unigene | Hs.136857 |
| MIM | 142210 |
| RefSeq mRNA | NM_005320.2 |
| RefSeq Protein | NP_005311.1 |
| Disease associations | No disease associations known for Histone H1.3 |
Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone