Histone H1.3

H1.3 expression is replication dependent. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). HL-60 and its differentiated cell types are shown to differ significantly in the presence of H1.3 variant (PMID: 11478838). H1.3 is detected in chromatin throughout the cell cycle whereas other varaints partition between chromatin and cytoplasm in a phase dependent manner (PMID: 20104577). Recent report classifies it as an intermediate condensor of chromatin (PMID: 19794910).

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Histone H1.3 infosheet
UniprotKB AccessionP16402
Alternative Name(s)Histone H1c
No. of coding genesHistone H1.3 is coded by following 1 non-allelic gene/s
Gene namehistone cluster 1, H1d
Gene symbolHIST1H1D
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sH1F3
Chromosomal location6p21.3
RefSeq mRNANM_005320.2
RefSeq ProteinNP_005311.1
Disease associationsNo disease associations known for Histone H1.3

Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone