Histone H1.2
H1.2 expression is replication dependent. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). H1.2 has another function apart from acting as a linker histone. It interacts directly with p53 and forms a repressor complex that represses transcription via multiple ways (PMID: 18258596). H1.2 is also shown to translocate inside mitochondria after sensing apoptotic signals (PMID: 17879944). Shown to be expressed at a higher level in many cell lines compared to other H1 variants (PMID: 9324306). H1.2 shows a dynamic exchange between chromatin and cytoplasm at different stages of mitotic phase (PMID: 20104577). A recent report classifies it as a weak condenser of chromatin (PMID: 19794910).
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| UniprotKB Accession | P16403 |
|---|---|
| Alternative Name(s) | Histone H1d |
| No. of coding genes | Histone H1.2 is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 1, H1c |
| Gene symbol | HIST1H1C |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H1F2 |
| Aliases | H1.2 |
| GeneID | 3006 |
| Chromosomal location | 6p21.3 |
| HGNC | 4716 |
| Unigene | Hs.7644 |
| MIM | 142710 |
| RefSeq mRNA | NM_005319.3 |
| RefSeq Protein | NP_005310.1 |
| Disease associations | No disease associations known for Histone H1.2 |
Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone