Histone H1.2

H1.2 expression is replication dependent. Its gene is present in cluster 1 on chromosome number 6 and its mRNA is not polyadenylated (PMID: 19587527). H1.2 has another function apart from acting as a linker histone. It interacts directly with p53 and forms a repressor complex that represses transcription via multiple ways (PMID: 18258596). H1.2 is also shown to translocate inside mitochondria after sensing apoptotic signals (PMID: 17879944). Shown to be expressed at a higher level in many cell lines compared to other H1 variants (PMID: 9324306). H1.2 shows a dynamic exchange between chromatin and cytoplasm at different stages of mitotic phase (PMID: 20104577). A recent report classifies it as a weak condenser of chromatin (PMID: 19794910).

Click on PTM for further information Notice: Use of undefined constant extract_pos - assumed 'extract_pos' in /var/home/coee/public_html/histome/variants.php on line 60 Notice: Use of undefined constant extract_pos_mod - assumed 'extract_pos_mod' in /var/home/coee/public_html/histome/variants.php on line 61

Download table as Excel
Histone H1.2 infosheet
UniprotKB AccessionP16403
Alternative Name(s)Histone H1d
No. of coding genesHistone H1.2 is coded by following 1 non-allelic gene/s
Gene namehistone cluster 1, H1c
Gene symbolHIST1H1C
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sH1F2
Chromosomal location6p21.3
RefSeq mRNANM_005319.3
RefSeq ProteinNP_005310.1
Disease associationsNo disease associations known for Histone H1.2

Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone