Histone H1.1
H1.1 expression is replication dependent. Its gene is present on cluster 1 on chromosome number 6 and mRNA is not polyadenylated (PMID: 19587527). Expressed in Hassall's corpuscles of the thymus and at a very low levels in human testis (PMID: 1626339, PMID: 9324306). There exists a rapid exchange of histone H1.1 on the chromatin fiber throughout the cell cycle (PMID: 11130728). A recent report classifies it as a weak condensor of chromatin (PMID: 19794910).
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| UniprotKB Accession | Q02539 |
|---|---|
| Alternative Name(s) | |
| No. of coding genes | Histone H1.1 is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 1, H1a |
| Gene symbol | HIST1H1A |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H1F1 |
| Aliases | H1.1 |
| GeneID | 3024 |
| Chromosomal location | 6p22.1 |
| HGNC | 4715 |
| Unigene | Hs.150206 |
| MIM | 142709 |
| RefSeq mRNA | NM_005325.3 |
| RefSeq Protein | NP_005316.1 |
| Disease associations | No disease associations known for Histone H1.1 |
Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone