Histone H1.5

H1.5 exhibits a replication dependent expression. Its gene is present in cluster 1 on chromosome number 6 and the mRNA is not polyadenylated (PMID: 19587527). Histone H1.5 expression is increased during early apoptosis (PMID: 9882631). H1.5 shows the maximum fold change in expression during S phase compared to other H1 variants (PMID: 9324306). H1.5 shows a dynamic exchange between chromatin and cytoplasm at different stages of mitosis (PMID: 20104577). A recent report classifies it as a strong condensor of chromatin (PMID: 19794910).

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Histone H1.5 infosheet
UniprotKB AccessionP16401
Alternative Name(s)Histone H1a
No. of coding genesHistone H1.5 is coded by following 1 non-allelic gene/s
Gene namehistone cluster 1, H1b
Gene symbolHIST1H1B
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sH1F5
Chromosomal location6p22.1
RefSeq mRNANM_005322.2
RefSeq ProteinNP_005313.1
Disease associationsNo disease associations known for Histone H1.5

Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone