Histone H1.5
H1.5 exhibits a replication dependent expression. Its gene is present in cluster 1 on chromosome number 6 and the mRNA is not polyadenylated (PMID: 19587527). Histone H1.5 expression is increased during early apoptosis (PMID: 9882631). H1.5 shows the maximum fold change in expression during S phase compared to other H1 variants (PMID: 9324306). H1.5 shows a dynamic exchange between chromatin and cytoplasm at different stages of mitosis (PMID: 20104577). A recent report classifies it as a strong condensor of chromatin (PMID: 19794910).
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| UniprotKB Accession | P16401 |
|---|---|
| Alternative Name(s) | Histone H1a |
| No. of coding genes | Histone H1.5 is coded by following 1 non-allelic gene/s |
| Gene name | histone cluster 1, H1b |
| Gene symbol | HIST1H1B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | H1F5 |
| Aliases | H1.5 |
| GeneID | 3009 |
| Chromosomal location | 6p22.1 |
| HGNC | 4719 |
| Unigene | Hs.131956 |
| MIM | 142711 |
| RefSeq mRNA | NM_005322.2 |
| RefSeq Protein | NP_005313.1 |
| Disease associations | No disease associations known for Histone H1.5 |
Histone H1 variants Histone H1.0, Histone H1.1, Histone H1.2, Histone H1.3, Histone H1.4, Histone H1.5, Histone H1oo, Histone H1t, Histone H1x, Testis-specific H1 histone