Seminars and Colloquia
Biology
A role of cellular translation regulation associated with toxic Huntingtin protein
Wed, Mar 25, 2020,
04:00 PM to 05:00 PM
at Seminar Room no. 34, Second Floor
Dr. Amitabha Majumdar
Wellcome trust-DBT Intermediate fellow and Scientist-D
at National Centre For Cell Science (NCCS), Pune
Abstract:
Huntington’s disease (HD) is a severe disorder caused by poly Q repeat expansion in the Huntingtin (Htt) gene. While the Htt amyloid aggregates are known to affect many cellular processes, their role in translation has not been addressed. In my talk, I will discuss how pathogenic Htt affects translation through probable sequestration of the translation regulator Orb2. I will also discuss how our observations using the Drosophila model might be relevant for human HD.
