Biology

Dr. Berryhill
Jackson Laboratory, USA

Highly immunodeficient mouse strains are enabling advanced models of human biology and disease.  Jax will introduce the NOD scid gamma (NSG) mouse as one of the most immunodeficient mice developed to date.  NSG mice have a long lifespan and support the engraftment of the widest range of human cells.  We will describe recent efforts to create a new set of patient-derived tumor models in this mouse.  Additionally, humanized immunity models can be efficiently established in NSG to understand hematopoiesis and studies of immune cell function.  We will show how both models can be combined for human cancer immunotherapy studies.  Finally, we will describe the various online resources that enable research with this mouse.