Seminars and Colloquia
Biology
Unveiling another dimension of transcription - G-quadruplex DNA structures are regulatory signposts genome-wide
Fri, Nov 17, 2017,
11:00 AM to 12:00 PM
at Seminar Room 34, 2nd Floor, Main Building
Dr. Shantanu Chowdhury
CSIR-Institute of Genomics and Integrative Biology, New Delhi
Transcription is typically studied as transcription factor(s) binding to cognate DNA sequence. We test the intriguing possibility that transcription is regulated by proteins engaging DNA structural motifs instead of sequence. Using the guanine quartet (G-quadruplex) motif we sought to analyse whether DNA structure impacts transcription. This was primarily based on the hypothesis that quadruplex DNA forms must engage trans-factors (proteins) for gene regulatory function. Observations test global DNA-protein interactions along with transcriptional status of human cells to lay a framework for DNA structure-mediated gene regulation.
