The Cancer Genome Atlas (TCGA) is a joint project of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). TCGA began in 2006 as a pilot project focused on three cancer types: lung, ovarian and glioblastoma. Due to the success of the initial efforts, TCGA was reauthorized for a full production phase in 2009. In the following decade, TCGA collected more than 11,000 cases across 33 tumor types, and generated a vast, comprehensive data set describing the molecular changes that occur in cancer. Tissue sample collection and data generation were completed in 2013 and 2016, respectively. Network maker papers, which are integrative cross-platform analyses of TCGA data on individual cancer types have been published for 33 of the tumor types to date (https://cancergenome.nih.gov/publications), as well as a cross-cancer overview published as 29 manuscripts in Cell publishing journals in Spring 2018.