Eyes absent homolog 2
EYA2 is involved in the dephosphorylation of histone H2A.X at the tyrosine 142 residue. It is involved in the DNA damage response (PMID: 19351884).
| UniprotKB Accession | O00167 | |
|---|---|---|
| Alternative Name(s) | ||
| Eraser for PTM/s | H2AY142ph | |
| EC number | 3.1.3.48 | |
| No. of coding genes | Eyes absent homolog 2 is coded by following 1 non-allelic gene/s | |
| Gene name | eyes absent homolog 2 (Drosophila) | |
| Gene symbol | EYA2 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | EAB1 | |
| GeneID | 2139 | |
| Chromosomal location | 20q13.1 | |
| HGNC | 3520 | |
| Unigene | Hs.472877 | |
| MIM | 601654 | |
| RefSeq mRNA | NM_005244.4 | NM_172110.3 |
| RefSeq Protein | NP_005235.3 | NP_742108.2 |
| Disease associations | Cancer: Lung adenocarcinoma; PMID: 19950702 | |
Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit