Histone-arginine methyltransferase CARM1
CARM1 belongs to the PRMT family of methyltransferases and catalyses monomethylation and asymmetric dimethylation of histone H3 at arginine 17 position and monomethylates arginine at position 2 and 26, which is reported to be linked to nuclear hormone receptor regulated transcriptional activation (PMID: 11751582, PMID: 16497732, PMID: 15186775). CARM1 methylates CREB-binding protein (CBP) in order to promote co-activation of transcription (PMID: 12374746). It is a part of nucleosomal methylation activator complex (NUMAC) which plays an important role in the regulation of nuclear-receptor signalling pathway (PMID: 14729568). CARM1 mediated methylation of H3R17 is involved in the activation of NF-kB target genes and also in the regulation of inflammatory genes in monocytes (PMID: 16497732). It also regulates E2F1, a transcription factor implicated in oestrogen dependent breast cancers (PMID: 18172323).
| UniprotKB Accession | Q86X55 |
|---|---|
| Alternative Name(s) | Coactivator-associated arginine methyltransferase 1, Protein arginine N-methyltransferase 4 |
| Writer for PTM/s | H3R17me1, H3R17me2, H3R2me1, H3R26me1 |
| EC number | 2.1.1.-, 2.1.1.125 |
| No. of coding genes | Histone-arginine methyltransferase CARM1 is coded by following 1 non-allelic gene/s |
| Gene name | coactivator-associated arginine methyltransferase 1 |
| Gene symbol | CARM1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PRMT4 |
| GeneID | 10498 |
| Chromosomal location | 19p13.2 |
| HGNC | 23393 |
| Unigene | Hs.323213 |
| MIM | 603934 |
| RefSeq mRNA | NM_199141.1 |
| RefSeq Protein | NP_954592.1 |
| Disease associations | Cancer: Prostate cancer; PMID: 16705743 Cancer: Colorectal cancer; PMID: 20462455 |
Arginine methyltransferases Histone-arginine methyltransferase CARM1, Protein arginine N-methyltransferase 1, Protein arginine N-methyltransferase 2, Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 7, Protein arginine N-methyltransferase 8