Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
PP2C catalyses the dephosphorylation gamma-H2AX and hence helps in clearing up of phosphorylated H2AX after efficient DNA repair. Its activity is independent of the other DNA damage response machinery. It also colocalises with the gamma-H2AX foci. (PMID: 16310392, PMID: 18614045).
| UniprotKB Accession | P67775 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | H2AS139ph |
| EC number | |
| No. of coding genes | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is coded by following 1 non-allelic gene/s |
| Gene name | protein phosphatase 2, catalytic subunit, alpha isozyme |
| Gene symbol | PPP2CA |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PP2Calpha |
| GeneID | 5515 |
| Chromosomal location | 5q31.1 |
| HGNC | 9299 |
| Unigene | Hs.105818 |
| MIM | 176915 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | Cancer: Prostate cancer; PMID: 17977648 |
Serine/threonine/tyrosine phosphatases Dual specificity protein phosphatase 1, Eyes absent homolog 1, Eyes absent homolog 2, Eyes absent homolog 3, Protein phosphatase 1D, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, Serine/threonine-protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 5, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit