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H2BK12ac

H2BK12 is shown to be heavily deacetylated on exposure to Nickel(II) which is supposed to be carcinogenic (PMID: 16283522). Shown to be enriched at the Transcription start site (TSS) and along gene bodies (PMID: 18552846). H2BK12 acetylation is found at differentially methylated regions of imprinted genes (PMID: 20693536).


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H2BK12ac infosheet
Modified variants Histone H2B type 1-B, Histone H2B type 1-C/E/F/G/I, Histone H2B type 1-D, Histone H2B type 1-H, Histone H2B type 1-J, Histone H2B type 1-K, Histone H2B type 1-L, Histone H2B type 1-M, Histone H2B type 1-N, Histone H2B type 1-O, Histone H2B type 2-E, Histone H2B type 2-F, Histone H2B type 3-B, Histone H2B type F-S, Putative histone H2B type 2-C, Putative histone H2B type 2-D
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Disease associationsNo disease associations known for H2BK12ac

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac