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Loss of H4K16 acetylation is a hallmark of human cancer (PMID: 15765097). SIRT1-dependent deacetylation of H4K16 is accompanied by Histone H1 recruitment and loss of H3K79 methylation leading to gene repression (PMID: 15469825). Shown to be enriched at the transcription start site (TSS) and along gene bodies (PMID: 18552846). It inhibits subsequent poly ADP-ribosylation by PARP1 (PMID: 20525793). H4K16ac, has a critical role at multiple stages in the cellular DNA damage response and DSB repair. (PMID: 20479123).

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H4K16ac infosheet
Modified variants Histone H4
Writer/s CREB-binding protein, Histone acetyltransferase KAT2A, Histone acetyltransferase p300, Probable histone acetyltransferase MYST1
Eraser/s NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2
Disease associations
Inflammatory bowel disorders: Crohn's disease; PMID: 21272292
Cancer: All; PMID: 15765097

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac