Probable histone acetyltransferase MYST1

MYST1 is also known as MOF. H4K16 acetylation mediated by MYST1 is crucial for DNA damage response and DNA double strand break responses (PMID: 20479123) (PMID: 17694080). mRNA and protein levels of MYST1 are found to be significantly reduced in primary breast carcinomas and medulloblastomas (PMID: 18058815). Downregultion of MOF causes significant decrease in H4K16 acetylation resulting in reduced transcription of cetain genes and cell cycle arrest in G2/M phase (PMID: 16227571).

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Probable histone acetyltransferase MYST1 (MYST-1) infosheet
UniprotKB AccessionQ9H7Z6
Alternative Name(s)MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 (hMOF)
Writer for PTM/s H4K16ac
EC number
No. of coding genesProbable histone acetyltransferase MYST1 is coded by following 1 non-allelic gene/s
Gene nameMYST histone acetyltransferase 1
Gene symbolMYST1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesMOF, FLJ14040, hMOF, KAT8
Chromosomal location16p11.1
RefSeq mRNANM_032188.2NM_182958.2
RefSeq ProteinNP_115564.2NP_892003.2
Disease associationsNo disease associations known for Probable histone acetyltransferase MYST1

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1