Histone acetyltransferase MYST4

MORF (Monocytic leukemia zinc finger protein-related factor) contains a functional histone acetyltransferase domain, a transcriptional repression domain at the N terminus and an activation domain at the C terminus. It majorly catalyse acetylation of histone H3 and H4 (PMID: 10497217). MORF has been shown to be disrupted in Uterine Leiomyomas (PMID: 15313893). MORF and MOZ together help in the regulation of Runx2 mediated transcriptinal activation (PMID: 11965546).

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Histone acetyltransferase MYST4 (MYST-4) infosheet
UniprotKB AccessionQ8WYB5
Alternative Name(s)Histone acetyltransferase MORF, Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, Monocytic leukemia zinc finger protein-related factor
Writer for PTM/s
EC number
No. of coding genesHistone acetyltransferase MYST4 is coded by following 1 non-allelic gene/s
Gene nameMYST histone acetyltransferase (monocytic leukemia) 4
Gene symbolMYST4
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Aliasesquerkopf, qkf, Morf, KAT6B, MOZ2
Chromosomal location10q22.2
RefSeq mRNANM_012330.2
RefSeq ProteinNP_036462.2
Disease associations
Cancer: Uterine leiomyoma; PMID: 19602464
Cancer: Acute myeloid leukaemia (AML); PMID: 12619164
Hematological disorder: Therapy-related myelodysplastic syndrome (t-MDS); PMID: 12542485

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1