Nuclear receptor coactivator 1

It majorly catalyses the acetylation of histone H3 and H4. SRC-1 possesses intrinsic histone acetyltransferase activity which helps to revert back the process of gene silencing. It facilitates formation of stable pre-initiation complex leading to transcriptional activation of specific gene targets of steroid receptors (PMID: 9296499).

Download table as Excel
Nuclear receptor coactivator 1 (NCoA-1) infosheet
UniprotKB AccessionQ15788
Alternative Name(s)Class E basic helix-loop-helix protein 74 (bHLHe74), Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1 (SRC-1)
Writer for PTM/s
EC number
No. of coding genesNuclear receptor coactivator 1 is coded by following 1 non-allelic gene/s
Gene namenuclear receptor coactivator 1
Gene symbolNCOA1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesSRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74
Chromosomal location2p23
RefSeq mRNANM_003743.4NM_147223.2NM_147233.2
RefSeq ProteinNP_003734.3NP_671756.1NP_671766.1
Disease associations
Cancer: Rhabdomyosarcoma; PMID: 15313887

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1