Nuclear receptor coactivator 3
ACTR exhibits histone acetyltransferase activity against histone H3 and H4 peptides. It can acetylate free as well as nucleosomal histones and associates with other HATs like CBP/p300/PCAF etc. Hence, it represents a mechanism of chromatin remodelling in hormone signalling (PMID: 9267036). ACTR is a proto-oncogene and is found to be over-expressed in breast cancers (PMID: 20124470).
| UniprotKB Accession | Q9Y6Q9 | |
|---|---|---|
| Alternative Name(s) | ACTR, Amplified in breast cancer 1 protein (AIB-1), CBP-interacting protein (pCIP), Class E basic helix-loop-helix protein 42 (bHLHe42), Receptor-associated coactivator 3 (RAC-3), Steroid receptor coactivator protein 3 (SRC-3), Thyroid hormone receptor activator molecule 1 (TRAM-1) | |
| Writer for PTM/s | ||
| EC number | 2.3.1.48 | |
| No. of coding genes | Nuclear receptor coactivator 3 is coded by following 1 non-allelic gene/s | |
| Gene name | nuclear receptor coactivator 3 | |
| Gene symbol | NCOA3 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 | |
| GeneID | 8202 | |
| Chromosomal location | 20q12 | |
| HGNC | 7670 | |
| Unigene | Hs.592142 | |
| MIM | 601937 | |
| RefSeq mRNA | NM_006534.3 | NM_181659.2 |
| RefSeq Protein | NP_006525.2 | NP_858045.1 |
| Disease associations | No disease associations known for Nuclear receptor coactivator 3 | |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1