Nuclear receptor coactivator 3

ACTR exhibits histone acetyltransferase activity against histone H3 and H4 peptides. It can acetylate free as well as nucleosomal histones and associates with other HATs like CBP/p300/PCAF etc. Hence, it represents a mechanism of chromatin remodelling in hormone signalling (PMID: 9267036). ACTR is a proto-oncogene and is found to be over-expressed in breast cancers (PMID: 20124470).

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Nuclear receptor coactivator 3 (NCoA-3) infosheet
UniprotKB AccessionQ9Y6Q9
Alternative Name(s)ACTR, Amplified in breast cancer 1 protein (AIB-1), CBP-interacting protein (pCIP), Class E basic helix-loop-helix protein 42 (bHLHe42), Receptor-associated coactivator 3 (RAC-3), Steroid receptor coactivator protein 3 (SRC-3), Thyroid hormone receptor activator molecule 1 (TRAM-1)
Writer for PTM/s
EC number
No. of coding genesNuclear receptor coactivator 3 is coded by following 1 non-allelic gene/s
Gene namenuclear receptor coactivator 3
Gene symbolNCOA3
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesRAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3
Chromosomal location20q12
RefSeq mRNANM_006534.3NM_181659.2
RefSeq ProteinNP_006525.2NP_858045.1
Disease associationsNo disease associations known for Nuclear receptor coactivator 3

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1