Histone acetyltransferase MYST2

Hbo1 belongs to the MYST class of acetyltransferases. It interacts with the origin recognition complex (ORC) and this interaction is evolutionarily conserved. Hence this ORC-mediated histone H4 acetylation is supposed to play a role in DNA replication via licensing of replication origins and gene regulation. It is responsible for the bulk acetylation of H4 (PMID: 10438470, PMID: 20129055). Hbo1 protein level is shown to be upregulated in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder (PMID: 19393168).

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Histone acetyltransferase MYST2 (MYST-2) infosheet
UniprotKB AccessionO95251
Alternative Name(s)Histone acetyltransferase binding to ORC1, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Writer for PTM/s H4K5ac, H4K8ac, H4K12ac
EC number
No. of coding genesHistone acetyltransferase MYST2 is coded by following 1 non-allelic gene/s
Gene nameMYST histone acetyltransferase 2
Gene symbolMYST2
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesHBOA, HBO1, KAT7
Chromosomal location17q21.32
RefSeq mRNANM_007067.4
RefSeq ProteinNP_008998.1
Disease associations
Cancer: Breast cancer; PMID: 21040551
Cancer: Multiple; PMID: 19393168

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1