Circadian locomoter output cycles protein kaput

CLOCK is a chief protein involved in establishing a circadian cycle in organisms. It associates with Bmal1. CLOCK protein catalyzes the acetylation of H3K14 in mice (PMID: 16678094). It is overexpressed in cisplatin resistant human cancer cells (PMID: 17297441).

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Circadian locomoter output cycles protein kaput (hCLOCK) infosheet
UniprotKB AccessionO15516
Alternative Name(s)Class E basic helix-loop-helix protein 8 (bHLHe8)
Writer for PTM/s H3K14ac
EC number
No. of coding genesCircadian locomoter output cycles protein kaput is coded by following 1 non-allelic gene/s
Gene nameclock homolog (mouse)
Gene symbolCLOCK
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesKIAA0334, KAT13D, bHLHe8
Chromosomal location4q12
RefSeq mRNANM_004898.2
RefSeq ProteinNP_004889.1
Disease associationsNo disease associations known for Circadian locomoter output cycles protein kaput

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1