Circadian locomoter output cycles protein kaput
CLOCK is a chief protein involved in establishing a circadian cycle in organisms. It associates with Bmal1. CLOCK protein catalyzes the acetylation of H3K14 in mice (PMID: 16678094). It is overexpressed in cisplatin resistant human cancer cells (PMID: 17297441).
| UniprotKB Accession | O15516 |
|---|---|
| Alternative Name(s) | Class E basic helix-loop-helix protein 8 (bHLHe8) |
| Writer for PTM/s | H3K14ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Circadian locomoter output cycles protein kaput is coded by following 1 non-allelic gene/s |
| Gene name | clock homolog (mouse) |
| Gene symbol | CLOCK |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0334, KAT13D, bHLHe8 |
| GeneID | 9575 |
| Chromosomal location | 4q12 |
| HGNC | 2082 |
| Unigene | Hs.436975 |
| MIM | 601851 |
| RefSeq mRNA | NM_004898.2 |
| RefSeq Protein | NP_004889.1 |
| Disease associations | No disease associations known for Circadian locomoter output cycles protein kaput |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1