CREB-binding protein
The acetyltrasferase activity of CBP is shown to be directly involved in transcriptional activation of genes (PMID: 9582282). CBP often acts in conjugation with p300. CBP/p300 associates with other histone acetyltransferases like PCAF. There are about 400 proteins that interact with CBP/p300 (PMID: 20110770). Mutations in CBP (some in the conserved HAT domain) are implicated in Rubinstein-Taybi Syndrome (RTS) (PMID: 15706485). RNA interference mediated knockdown of CBP and p300 in immortal HeLa cells results in cell death due to "mitotic catastrophe" and "chromosome shredding"(PMID: 17272271). Artificial enhancement of the HAT activity of CBP via Phenylephrine has been shown to induce cardiac hypertrophy (PMID: 12477714). Acetylation of different lysine residues of histone H3 and H4 by CBP/p300 at the site of double stranded DNA breaks generated during IR radiation have been shown to recruite SWI/SNF chromatin remodellers for DNA repair. Hence, inhibition of CBP activity can help is sensitising cancer cells to radiotherapy or chemotherapy (PMID: 21217779).
| UniprotKB Accession | Q92793 | |
|---|---|---|
| Alternative Name(s) | ||
| Writer for PTM/s | H3K27ac, H3K56ac, H3K18ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac | |
| EC number | 2.3.1.48 | |
| No. of coding genes | CREB-binding protein is coded by following 1 non-allelic gene/s | |
| Gene name | CREB binding protein | |
| Gene symbol | CREBBP | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | RSTS | |
| Aliases | RTS, CBP, KAT3A | |
| GeneID | 1387 | |
| Chromosomal location | 16p13.3 | |
| HGNC | 2348 | |
| Unigene | Hs.459759 | |
| MIM | 600140 | |
| RefSeq mRNA | NM_001079846.1 | NM_004380.2 |
| RefSeq Protein | NP_001073315.1 | NP_004371.2 |
| Disease associations | Cancer: Epithelial cancer; PMID: 12402157 Cancer: Lung cancer; PMID: 15701835 Cancer: Acute myeloid leukemia; PMID: 10469454 Cancer: Acute myeloid leukemia; PMID: 9447825 Cancer: Acute myeloid leukemia; PMID: 8782817 Cancer: Acute myeloid leukemia; PMID: 12619164 Hematological disorder: Myelodysplastic syndrome; PMID: 12542485 Cancer: Esophageal carcinoma; PMID: 14734447 Cancer: Colon cancer; PMID: 14732695 Cancer: Therapy related leukemia; PMID: 9226152 Developmental disorder: RTS (Rubinstein- Taybi syndrome); PMID: 7630403 | |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1