Histone acetyltransferase type B catalytic subunit

Also known as Hat1. It is present subcellularly and acetylates the soluble histone H4/H2A and not the nucleosomal fraction. Acetylation by Hat1 might be involved in the silencing of cells that were earlier transcriptionally active (PMID: 9427644). Hat1 is shown to be upregulated distinctly both at transcript and protein level in human colorectal cancer tissues (PMID: 16158056, PMID: 17694075).

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Histone acetyltransferase type B catalytic subunit infosheet
UniprotKB AccessionO14929
Alternative Name(s)
Writer for PTM/s H4K5ac, H4K12ac, H2AK5ac
EC number
No. of coding genesHistone acetyltransferase type B catalytic subunit is coded by following 1 non-allelic gene/s
Gene namehistone acetyltransferase 1
Gene symbolHAT1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location2q31.2-q33
RefSeq mRNANM_003642.3
RefSeq ProteinNP_003633.1
Disease associations
Cancer: Colorectal cancer; PMID: 16158056

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1