Histone acetyltransferase MYST3

MOZ (Monocytic leukaemia Zinc-finger protein) belongs to the MYST histone acetyltransferase family. Its role has been implicated in normal as well as malignant hematopoiesis (PMID: 18754862). MOZ-CBP fusion protein is formed during translocation events associated with leukemia and it antagonises the AML-1 complex required for differentiation. This activity is not associated with the HAT domain of MOZ (PMID: 11742995). MOZ along with MLL, has been shown to regulate key transcription factors for Hox gene expression in human cord blood CD34+ cells which are critical for leukemogenesis (PMID: 20581860). MORF is reported to be disrupted in uterine leiomyomas (PMID: 15313893). MORF and MOZ together help in the regulation of Runx2 mediated transcriptional activation (PMID: 11965546).

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Histone acetyltransferase MYST3 (MYST-3) infosheet
UniprotKB AccessionQ92794
Alternative Name(s)MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220
Writer for PTM/s H3K14ac
EC number
No. of coding genesHistone acetyltransferase MYST3 is coded by following 1 non-allelic gene/s
Gene nameMYST histone acetyltransferase (monocytic leukemia) 3
Gene symbolMYST3
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sZNF220, RUNXBP2
AliasesMOZ, KAT6A
Chromosomal location8p11
RefSeq mRNANM_001099412.1NM_001099413.1NM_006766.3
RefSeq ProteinNP_001092882.1NP_001092883.1NP_006757.2
Disease associations
Cancer: Hepatocellular carcinoma; PMID: 17083329
Cancer: Acute lymphoid leukemia (ALL); PMID: 18818702
Cancer: Acute myeloid leukaemia (AML); PMID: 8782817

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1