Histone acetyltransferase MYST3
MOZ (Monocytic leukaemia Zinc-finger protein) belongs to the MYST histone acetyltransferase family. Its role has been implicated in normal as well as malignant hematopoiesis (PMID: 18754862). MOZ-CBP fusion protein is formed during translocation events associated with leukemia and it antagonises the AML-1 complex required for differentiation. This activity is not associated with the HAT domain of MOZ (PMID: 11742995). MOZ along with MLL, has been shown to regulate key transcription factors for Hox gene expression in human cord blood CD34+ cells which are critical for leukemogenesis (PMID: 20581860). MORF is reported to be disrupted in uterine leiomyomas (PMID: 15313893). MORF and MOZ together help in the regulation of Runx2 mediated transcriptional activation (PMID: 11965546).
| UniprotKB Accession | Q92794 | ||
|---|---|---|---|
| Alternative Name(s) | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220 | ||
| Writer for PTM/s | H3K14ac | ||
| EC number | 2.3.1.48 | ||
| No. of coding genes | Histone acetyltransferase MYST3 is coded by following 1 non-allelic gene/s | ||
| Gene name | MYST histone acetyltransferase (monocytic leukemia) 3 | ||
| Gene symbol | MYST3 | ||
| Promoter region (-700 TSS +300) | Get sequence | ||
| Previous Symbol/s | ZNF220, RUNXBP2 | ||
| Aliases | MOZ, KAT6A | ||
| GeneID | 7994 | ||
| Chromosomal location | 8p11 | ||
| HGNC | 13013 | ||
| Unigene | Hs.491577 | ||
| MIM | 601408 | ||
| RefSeq mRNA | NM_001099412.1 | NM_001099413.1 | NM_006766.3 |
| RefSeq Protein | NP_001092882.1 | NP_001092883.1 | NP_006757.2 |
| Disease associations | Cancer: Hepatocellular carcinoma; PMID: 17083329 Cancer: Acute lymphoid leukemia (ALL); PMID: 18818702 Cancer: Acute myeloid leukaemia (AML); PMID: 8782817 | ||
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1